Roberto Martinez described his team’s 2-1 triumph at QPR as his most satisfying win since taking over as Everton manager.The Merseysiders, who went out of the Europa League against Dynamo Kiev in Ukraine on Thursday, were victorious at Loftus Road courtesy of Aaron Lennon’s 77th-minute goal.“It was probably our most satisying win since I’ve been at Everton for many reasons,” Martinez said.“The amount of emotions we shared on Thursday, we got back really late and this season we have found it difficult to get a win after European games.“We are adapting to being a team that is competing in Europe and in domestic competitions.“We had to cope with the goalscoring threat Queens Park Rangers are going to throw at you. It wasn’t a day for a technical performance – we had to be a strong group of players.”Martinez added that Everton striker Arouna Kone will be assessed after suffering what looked like a nasty knee injury, while Romelu Lukaku is nursing a hamstring strain.See also:Everton condemn QPR to another home lossFollow West London Sport on TwitterFind us on Facebook
(Visited 17 times, 1 visits today)FacebookTwitterPinterestSave分享0 Scientists at MIT publishing in PNAS1 detected instances of alternative splicing in over 1,000 genes of stem cells. They also computed possible isoforms of mRNA transcriptions and found 80% of them in the cells. Not only that, the isoforms (alternatively spliced versions of exons from the same gene) appeared to be functional: “We find that alternative splicing can modify multiple components of signaling pathways important for stem cell function,” they say. In short, alternative splicing, in which exons from genes are recombined in different ways, expands the information content of the genome:We also analyze the distribution of splice variants across different classes of genes. We find that tissue-specific genes have a higher tendency to undergo alternative splicing than ubiquitously expressed genes. Furthermore, the patterns of alternative splicing are only weakly conserved between orthologous genes in human and mouse. Our studies reveal extensive modification of the stem cell molecular repertoire by alternative splicing and provide insights into its overall role as a mechanism of generating genomic diversity. (Emphasis added in all quotes.)They took note that “different mRNA isoforms from a single gene can often encode proteins with distinct, sometimes opposite functions.” In fact, they point to earlier research that said, “Numerous biological processes ranging from sex determination to apoptosis depend on the alternative splicing of specific genes.” Later, they said, “alternative splicing was found to extensively affect components of signaling pathways that are functional in stem cells, suggesting an important role of splice variations in self-renewal and differentiation.” Thus, their work adds to a growing body of research showing that “alternative splicing is a general mechanism to increase the coding capacity and diversity of the genome in metazoans.” What regulates how the exons are spliced? “Previous studies of individual genes have shown that splicing is coupled to transcription by protein-protein interactions between components of the transcription and splicing complexes.” Their work suggested that tissue-specific genes seem to undergo the most alternative splicing, and ubiquitously-expressed genes less so. They offered an “evolutionary argument” that tissue-specific genes could afford more experimentation: “ubiquitous transcripts responsible for crucial and general cellular processes have evolved not to be modified, whereas diversification is advantageous for tissue-specific gene products.” This hypothesis, they felt, was reinforced by the finding that “patterns were conserved for only 20% of the examined orthologous genes in the human and mouse species, despite the general conservation of their exon-intron boundaries.” This, they feel, could lead to rapid evolution of alternatively spliced exons, and subsequently to functional differences in otherwise analogous cell types between distant species.1Pritzker et al., “Diversification of stem cell molecular repertoire by alternative splicing,” Proceedings of the National Academy of Sciences USA, 10.1073/pnas.0502132102, published online before print September 23, 2005.These findings add to the growing realization that the genome contains much more embedded information than mere gene count would suggest (see 09/08/2005 entry). If the introns themselves (02/18/2005, 02/02/2005) transcribe into RNA regulatory elements, then nothing is wasted, and nothing is junk. If all parts of the system can be shown to produce function, it becomes harder to claim evolution built this tight ship. These authors’ weak attempt to produce an “evolutionary argument” did not demonstrate that any heritable, functional advantage derived from mistakes in alternative splicing, but only that it could have. Did they demonstrate an example of a new function arising from a mistake? No; they just expressed faith that randomness creates the possibility space for order. This is a doctrine of pantheism (a religion). On the other hand, the high degree of conservation found in ubiquitously-expressed genes and at intron-exon boundaries are anti-evolutionary observations. To argue evolution out of this data is to rely again on slippery homology vs. analogy arguments (see “Homology for Dummies,” 05/05/2004). Because such arguments depend on embedded evolutionary assumptions, they are inherently circular. It is just as logical to conclude that a common Designer built the system around two principles: (1) modular construction, wherein commonly-needed functions are coded similarly between different organisms, and (2) robustness, in which regulatory networks can maintain stability in changing environments. The design inference has the added advantage of an adequate cause for the high degree of information involved. Whatever geneticists continue to uncover about the particulars, the system works. Somehow, a human genome gives rise to a human, and a mouse genome gives rise to a mouse. Unless mutations disrupt the program, the mouse will have all the parts in the right places. It will be covered with the right kind of fur, have the right teeth in the right order, have feet and muscles and eyes and a brain and every organ necessary for its little life. The molecular processes may seem disorganized to us. We see that one gene can be alternatively spliced into several products, some which can produce opposite functions. How does the right one get selected at the right time it is needed? There are wonderful mysteries here that could be illuminated by a scientist looking for intelligent design. If the DNA is not the master controller of its own transcription, what is? What controls the spliceosome? (09/17/2004). Can protein-protein interactions really be responsible for regulating the splicing, or is there another layer of genetic information directing their interplay? What do all those short non-coding RNAs do? How can so many competing processes and such a multiplicity of molecules guarantee a working mouse at the end of the assembly line? We see only glimpses of how the plethora of processes at the molecular level leads invariably to the right result. There may be more information and more design operating than we can possibly imagine.
Brace for potentially devastating typhoon approaching PH – NDRRMC The Bolts haven’t seen action since Aug. 18, when they nipped Phoenix Petroleum, 107-104, and it is a layoff that was a welcome one as far as coach Norman Black is concerned as it allowed injuries on some players to heal. WATCH: Streetboys show off slick dance moves in Vhong Navarro’s wedding Trending Articles PLAY LIST 00:50Trending Articles00:50Trending Articles00:50Trending Articles01:37Protesters burn down Iran consulate in Najaf01:47Panelo casts doubts on Robredo’s drug war ‘discoveries’01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games Catriona Gray spends Thanksgiving by preparing meals for people with illnesses LOOK: Venues for 2019 SEA Games LATEST STORIES Kammuri turning to super typhoon less likely but possible — Pagasa View comments Kelly Williams will man the post for TNT KaTropa in their game against Meralco Wednesday night. —SHERWIN VARDELEONMeralco tangles with struggling sister team TNT KaTropa on Wednesday, seeking a win to formally advance to the quarterfinals of the PBA Governors’ Cup at Smart Araneta Coliseum.Tip-off is at 4:15 p.m., with the Bolts shooting to become the third team to earn safe passage to the next round, and, more importantly, stay in the hunt for a top four finish which carries a twice-to-beat advantage in the first round of the playoffs.ADVERTISEMENT Read Next UPLB exempted from SEA Games class suspension Meanwhile, San Miguel Beer, chasing to complete a rare Triple Crown sweep, will most likely play Terik Bridgeman against Rain or Shine in the 7 p.m. contest as the Beermen await the arrival of new import Terrence Watson.Bridgeman, who came in to replace Wendell McKines, was a huge disappointment in his debut last Saturday, scoring just two points and grabbing six rebounds in a 90-79 loss to Alaska in Angeles City in Pampanga.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutoutManagement and coaching staff wasted no time and shopped around for a replacement, their third import in the season-closing conference. Watson is expected to plane in either late Tuesday or early Wednesday from the United States.But a ranking team official told the Inquirer that the Beermen would likely play Bridgeman against the Elasto Painters because coaching staff doesn’t feel that Watson would be able to have at least one practice with the team. SEA Games in Calabarzon safe, secure – Solcom chief Azkals eye Mid East training Typhoon Kammuri accelerates, gains strength en route to PH MOST READ Don’t miss out on the latest news and information.
About the authorPaul VegasShare the loveHave your say Bournemouth boss Howe delighted with Fraser formby Paul Vegas10 months agoSend to a friendShare the loveBournemouth boss Eddie Howe is delighted with the form of Ryan Fraser.The Scotland international has been a regular presence under Howe this season and is level with Eden Hazard for most assists in the Premier League this season with nine.”He’s done so well this [season], he’s been a regular goal creator, goal scorer and his set-piece delivery has been excellent, which was evident on Wednesday,” Howe said.”Two lovely free-kicks, one floated and one whipped, with two goals coming from that. So really pleased.”I’m not surprised [by his performances]. His technical ability is so high; he’s got two lovely feet and a very good football brain.”It was more a case of wanting him to show everybody what he can do on a consistent basis and he’s started to do it this [season].”
Yesterday TMZ got its hands on the mug shot of boxing champion Floyd Mayweather Jr., taken moments after he turned himself into police to begin his 87-day jail sentence in Las Vegas stemming from a domestic dispute.Mayweather allegedly beat up the mother of his children while they stood by watching. While incarcerated, Mayweather initially will be kept out of general population to avoid conflicts with other inmates.He was sentenced to 90 days but received credit for three days already served.
After 21 years under the watch of John Bluem, Ohio State found a new men’s soccer head coach Monday.The Buckeyes announced the hire of former Indiana associate head coach Brian Maisonneuve as the 10th coach in program history. He spent the past 10 years guiding the Hoosiers to eight NCAA tournament appearances including their victorious 2012 NCAA national championship and a runner-up finish in the 2017 season.“I am excited to get to work and continue to grow the Ohio State program into one of the elite soccer programs in the country,” Brian Maisonneuve said in a statement. “John [Bluem] did a great job over the last 21 years and I am so honored for this opportunity. This is an incredible athletics department with tremendous resources.”Maisonneuve was an All-American as a player for the Hoosiers during his four-year tenure on the team from 1991 to 1994, and his success does not stop there. After playing at Indiana, Maisonneuve went to play for the Columbus Crew from 1996 to 2004. He also was a member of the 1996 U.S. Olympic team and the 1998 U.S. World Cup team. When his playing days were done, he coached for five years before joining the Hoosiers. He led the Hoosiers to eight NCAA tournaments throughout his time as a coach.He will fit perfectly as the next in line of a successful coaching history. “We are fortunate to add Brian Maisonneuve to our outstanding lineup of head coaches,” Ohio State Athletics Director Gene Smith said in a statement. “He has competed at a high level and coached in one of the most successful collegiate programs nationally. We look forward to the opportunities our student-athletes will have under Brian’s direction.” Maisonneuve has received multiple coaching awards throughout his career including the NSCAA Assistant Coach of the Year for the Great Lakes Region in 2012 and 2015. He was also named one of the top 12 assistants in the nation for the third straight year and fifth time in his career in 2016.
Facebook Twitter Google+LinkedInPinterestWhatsAppProvidenciales, 03 Feb 2015 – Thwarting bribes was the focus of a two day workshop held recently at Blue Haven resort and hosted by the UK Ministry of Justice. Some thirty actors from the TCI private and public sector were a part of the sessions where Roderick Maccauley and Peter Monday of the UK, led the sessions which dealt with international perspectives on bribery, how to enforce anti-bribery legislation, a review of the UK’s Bribery Act 2010 and Corporate liability and incentives. The governor was on hand, and welcomed the delegates for the workshop, which was the second to be held in a Caribbean UK Overseas Territory; the first was delivered in Bermuda. Facebook Twitter Google+LinkedInPinterestWhatsApp Related Items:bribes, ministry of justice, peter monday, Roderick Maccauley
Facebook0TwitterEmailPrintFriendly分享Governor Mike Dunleavy signed a reduced final capital budget by $34.7 M through his line-item veto authority into law on Thursday. In a release from the office of the governor, SB2002, as passed by the Alaska Legislature, included a number of projects of local, community or legislative interest that the state simply cannot fund under its limited financial resources. Dunleavy’s office said the remaining capital budget, signed Thursday, captures nearly $1 billion in federal dollars and funds sweeping crime legislation. Governor Dunleavy: “In the coming days and weeks, my administration will be making more decisions that will impact Alaskans – but our commitment remains to be open to input from Alaskans, to understand their priorities, and to work towards achieving better outcomes for the dollars we do spend. While Alaskans await future announcements regarding the operating budget, we can’t ignore the fact that today’s action represents an important and positive step in moving Alaska forward.” Click here for additional on the enacted Fiscal Year 2020 capital budget, including a funded project summary, a vetoed project summary and more. Key items funded in SB 2002: $73M to Federal Highway and Aviation Match, which secures $877.2 million in Federal funds$12M to Village Safe Water and Wastewater Projects, securing over $52M in Federal funds$2.54M to Hiland Mountain Women’s Mental Health Unit$2M in AIDEA receipts for Northwest Arctic Borough school construction and major maintenance$680,200 to Electronic Visit Verification System$2.5M to Arctic Strategic Transportation and Resources$1.5M to AHFC Rental Assistance for Victims- Empowering Choice Housing Program$3.6M to AHFC Homeless Assistance$1.75M to AHFC Senior Citizen Housing$250,000 to Inter-Island Ferry Authority$13.5M to Alaska Marine Highway System vessel overhaul, annual certification, and shoreside facilities rehabilitation$1.6M to Harbor Grant Program
The highway between Sterling and Cooper Landing has been opening and closing as conditions in the area change due to activity and smoke from the Swan Lake fire. Facebook0TwitterEmailPrintFriendly分享Fire Chief Michelle Weston with the Girdwood Fire Department took to social media to urge residents to avoid any non-necessary trip through an area with active fire, saying “Your life is worth more than any non-necessary trip”. The Swan Lake Fire is currently at 158,042 acres with 20% containment. Residents have taken to Facebook to post photos and videos while driving through highly active fire situations along the Sterling Highway. Travel on the Sterling Highway from Watson Lake to the Seward Hwy (MP 71-26) is NOT advised and is “subject to change at any time”. Weston: “We have many large fires impacting the Parks and Sterling Highways right now. Fire Conditions and wind directions can change very quickly with wind and these extremely dry fuel conditions. Fires also create their own wind dynamics.As Alaskans we expect our highways to be open to travel no matter if there is zero visibility from snow white outs or extreme fire behavior or major fatality accidents.As the public, you need to know that an open highway, may not necessarily be a safe highway.Please plan carefully your trips through areas of active fire if you have a vehicle prone to breaking down, or family members with difficulty breathing, or are not good at driving in low visibility. A vehicle accident in these conditions could prove fatal.As firefighters we see many people die tragically on a weekly basis. We just want you all to stay safe, and stay on this earth as long as you can for those who love you.Stay safe, minimize risk and we will all get through this fire season like we did the earthquake.”
Third-grader’s marriage foiled A class-three girl was saved from early marriage at Puthiabaria in the municipality area on Friday thanks to the prompt action of the local administration.Executive magistrate Anisur Rahman foiled the marriage of 11-year-old Banna Khatun with Abdur Rahman, 18, of the same area.The would-be groom and his relatives fled after the magistrate arrived.The mobile court fined the girl’s father Muktar Hossain Tk 5,000. It took undertakings from Banna and Rahman’s fathers who promised not to marry off their underage children before they reach adulthood.