Alli ended a 15-game goal drought when he scored in the 4-1 win at Bournemouth on Sunday and has been given a glowing endorsement by his boss.Pochettino said there is no other player in the world at Alli’s age who can match his achievements, despite the rival claims of the likes of Leroy Sane, Gabriel Jesus, Kylian Mbappe, Ousmane Dembele and Marcus Rashford.“When you compare him, Dele Alli, 21 years old, with all the players in the world, not only in Europe, in the world, I think he is the best,” the Argentine said.“In his age, in his form, assists and everything. But, and I don’t understand why, there is still that feeling (to criticise him). For me, Dele Alli, for his age, is the best. That’s it.“Tell me one better than him, a 21-year-old, all that he achieves. Tell me one. A current player. Maybe you can find similar or better than him?”While Alli’s displays have come under scrutiny from fans and the media, Pochettino said his opinion is the one that matters most“I promise you, I am the most critical person with my players,” said the Spurs boss. “But it is difficult to criticise Dele.“The most important for him is us, if we criticise him. If we are not happy with him, that is what is important for him and we never criticise him.”It is not clear whether Alli will feature in Tottenham’s FA Cup tie at Swansea on Saturday.The midfielder was suffering with a tight groin after last week’s win but is fit and has been named in England’s squad for friendlies against the Netherlands and Italy.“He played a lot of games, international games,” Pochettino said. “Now, we will see for Saturday because in the end, he’s going to play for the national team, and they are not machines.”Kane has suffered lateral ligament damage in his right ankle and is expected to return to training next month.0Shares0000(Visited 1 times, 1 visits today) 0Shares0000Tottenham midfielder Dele Alli © AFP/File / Glyn KIRKLONDON, United Kingdom, Mar 16 – Tottenham manager Mauricio Pochettino has hailed Dele Alli as the best young player in the world as he rejigs his side to cope with the absence of the injured Harry Kane.The 21-year-old Alli has been criticised for some inconsistent performances this season for a Spurs side chasing a top-four spot in the Premier League and in FA Cup quarter-final action this weekend.
Branislav Ivanovic missed a good chance to give Chelsea the lead in the west London derby at Stamford Bridge.The Serbian defender, unmarked at the near post, fired into the side netting from close range after being found by Willian’s cross.Willian was involved in creating an earlier chance for Oscar, who scuffed a shot wide after Diego Costa had cleverly flicked the ball into his path.At the other end, Charlie Austin headed over from Junior Hoilett’s cross.Costa is back in the Chelsea side following a hamstring problem, while Hoilett came in for Bobby Zamora, who is among the QPR substitutes. Chelsea: Courtois; Ivanovic, Cahill, Terry, Filipe Luis; Matic, Fabregas; Willian, Oscar, Hazard; Costa.Subs: Cech, Zouma, Ake, Ramires, Salah, Schurrle, Drogba. QPR: Green, Isla, Caulker, Dunne, Yun, Hoilett, Sandro, Fer, Vargas, Austin.Subs: Murphy, Traore, Hill, Phillips, Wright-Phillips, Kranjcar, Zamora.Follow West London Sport on TwitterFind us on Facebook
Roberto Martinez described his team’s 2-1 triumph at QPR as his most satisfying win since taking over as Everton manager.The Merseysiders, who went out of the Europa League against Dynamo Kiev in Ukraine on Thursday, were victorious at Loftus Road courtesy of Aaron Lennon’s 77th-minute goal.“It was probably our most satisying win since I’ve been at Everton for many reasons,” Martinez said.“The amount of emotions we shared on Thursday, we got back really late and this season we have found it difficult to get a win after European games.“We are adapting to being a team that is competing in Europe and in domestic competitions.“We had to cope with the goalscoring threat Queens Park Rangers are going to throw at you. It wasn’t a day for a technical performance – we had to be a strong group of players.”Martinez added that Everton striker Arouna Kone will be assessed after suffering what looked like a nasty knee injury, while Romelu Lukaku is nursing a hamstring strain.See also:Everton condemn QPR to another home lossFollow West London Sport on TwitterFind us on Facebook
(Visited 17 times, 1 visits today)FacebookTwitterPinterestSave分享0 Scientists at MIT publishing in PNAS1 detected instances of alternative splicing in over 1,000 genes of stem cells. They also computed possible isoforms of mRNA transcriptions and found 80% of them in the cells. Not only that, the isoforms (alternatively spliced versions of exons from the same gene) appeared to be functional: “We find that alternative splicing can modify multiple components of signaling pathways important for stem cell function,” they say. In short, alternative splicing, in which exons from genes are recombined in different ways, expands the information content of the genome:We also analyze the distribution of splice variants across different classes of genes. We find that tissue-specific genes have a higher tendency to undergo alternative splicing than ubiquitously expressed genes. Furthermore, the patterns of alternative splicing are only weakly conserved between orthologous genes in human and mouse. Our studies reveal extensive modification of the stem cell molecular repertoire by alternative splicing and provide insights into its overall role as a mechanism of generating genomic diversity. (Emphasis added in all quotes.)They took note that “different mRNA isoforms from a single gene can often encode proteins with distinct, sometimes opposite functions.” In fact, they point to earlier research that said, “Numerous biological processes ranging from sex determination to apoptosis depend on the alternative splicing of specific genes.” Later, they said, “alternative splicing was found to extensively affect components of signaling pathways that are functional in stem cells, suggesting an important role of splice variations in self-renewal and differentiation.” Thus, their work adds to a growing body of research showing that “alternative splicing is a general mechanism to increase the coding capacity and diversity of the genome in metazoans.” What regulates how the exons are spliced? “Previous studies of individual genes have shown that splicing is coupled to transcription by protein-protein interactions between components of the transcription and splicing complexes.” Their work suggested that tissue-specific genes seem to undergo the most alternative splicing, and ubiquitously-expressed genes less so. They offered an “evolutionary argument” that tissue-specific genes could afford more experimentation: “ubiquitous transcripts responsible for crucial and general cellular processes have evolved not to be modified, whereas diversification is advantageous for tissue-specific gene products.” This hypothesis, they felt, was reinforced by the finding that “patterns were conserved for only 20% of the examined orthologous genes in the human and mouse species, despite the general conservation of their exon-intron boundaries.” This, they feel, could lead to rapid evolution of alternatively spliced exons, and subsequently to functional differences in otherwise analogous cell types between distant species.1Pritzker et al., “Diversification of stem cell molecular repertoire by alternative splicing,” Proceedings of the National Academy of Sciences USA, 10.1073/pnas.0502132102, published online before print September 23, 2005.These findings add to the growing realization that the genome contains much more embedded information than mere gene count would suggest (see 09/08/2005 entry). If the introns themselves (02/18/2005, 02/02/2005) transcribe into RNA regulatory elements, then nothing is wasted, and nothing is junk. If all parts of the system can be shown to produce function, it becomes harder to claim evolution built this tight ship. These authors’ weak attempt to produce an “evolutionary argument” did not demonstrate that any heritable, functional advantage derived from mistakes in alternative splicing, but only that it could have. Did they demonstrate an example of a new function arising from a mistake? No; they just expressed faith that randomness creates the possibility space for order. This is a doctrine of pantheism (a religion). On the other hand, the high degree of conservation found in ubiquitously-expressed genes and at intron-exon boundaries are anti-evolutionary observations. To argue evolution out of this data is to rely again on slippery homology vs. analogy arguments (see “Homology for Dummies,” 05/05/2004). Because such arguments depend on embedded evolutionary assumptions, they are inherently circular. It is just as logical to conclude that a common Designer built the system around two principles: (1) modular construction, wherein commonly-needed functions are coded similarly between different organisms, and (2) robustness, in which regulatory networks can maintain stability in changing environments. The design inference has the added advantage of an adequate cause for the high degree of information involved. Whatever geneticists continue to uncover about the particulars, the system works. Somehow, a human genome gives rise to a human, and a mouse genome gives rise to a mouse. Unless mutations disrupt the program, the mouse will have all the parts in the right places. It will be covered with the right kind of fur, have the right teeth in the right order, have feet and muscles and eyes and a brain and every organ necessary for its little life. The molecular processes may seem disorganized to us. We see that one gene can be alternatively spliced into several products, some which can produce opposite functions. How does the right one get selected at the right time it is needed? There are wonderful mysteries here that could be illuminated by a scientist looking for intelligent design. If the DNA is not the master controller of its own transcription, what is? What controls the spliceosome? (09/17/2004). Can protein-protein interactions really be responsible for regulating the splicing, or is there another layer of genetic information directing their interplay? What do all those short non-coding RNAs do? How can so many competing processes and such a multiplicity of molecules guarantee a working mouse at the end of the assembly line? We see only glimpses of how the plethora of processes at the molecular level leads invariably to the right result. There may be more information and more design operating than we can possibly imagine.
27 June 2005President Thabo Mbeki lit a flame of freedom in Kliptown, Soweto on Sunday to mark the official opening of the Walter Sisulu Square of Dedication, the site of the Freedom Charter monument.The Charter, adopted by a People’s Congress of thousands on 26 June 1955, is seen by many as the foundation of South Africa’s 1996 Constitution.Kliptown and the Freedom CharterOn 26 June 1955 over 3 000 people made their way through police cordons to gather in a dusty square in Kliptown to draw up the Freedom Charter.Accompanied by former president Nelson Mandela and Albertina Sisulu, the wife of the late struggle hero Walter, Mbeki first read the wall of remembrance of the historic event, the Freedom Charter.The President then lit the “flame of freedom” to symbolise the opening of the Square before unveiling a plaque in honour of Walter Sisulu, who died in 2003.Sitting in a wheelchair, Albertina Sisulu said she was happy that she had “seen this” and was thankful to the people of South Africa for remembering her husband in such a manner.Addressing the 20 000-strong crowd, Mbeki said the adoption of the Freedom Charter was a commitment to accomplish the noble vision spelt out in the document.In the same way that it took time and great sacrifices for the country to achieve liberation, Mbeki said, so it would take time and demand new sacrifices to fully translate into reality the vision, born in struggle, represented by the Freedom Charter.On Monday, Cabinet ministers will gather in a multipurpose hall overlooking the square for a formal sitting of Parliament – the first time that the National Assembly and National Council of Provinces will have a joint sitting outside Cape Town.Kliptown urban renewal projectThe Walter Sisulu square forms part of the Kliptown urban renewal project, an initiative supported by the provincial government and the city of Johannesburg to the tune of R160-million.“Kliptown is undergoing major infrastructural, environmental and economic development aimed at transforming it into a significant tourist destination and heritage site, as well as prosperous residential and commercial area,” Gauteng Housing MEC Nomvula Mokonyane said last week.The development programme aims to integrate the area’s local economy with that of greater Johannesburg, creating business opportunities and employment in the retail, manufacturing, tourism, transport, services and construction industries, and increasing transport efficiencies to and within Kliptown.It includes providing new housing, rehabilitating the Kliptown River, cleaning up the wetlands and creating a green space for recreation.The square, already proclaimed a national heritage site, will feature two squares representing the period of transition.Its 10 pillars represent the clauses of the Freedom Charter, while paving featuring crosses celebrate the freedom to vote.The site will be used as a gathering place and venue for concerts and other cultural events.BuaNews and SouthAfrica.info reporter
Share Facebook Twitter Google + LinkedIn Pinterest In December, the Eaton MVCTC FFA chapter delivered fresh flower bouquets and a table centerpieces to local businesses in Eaton for the holidays.The flowers and greenery came from Eaton’s agriculture education classroom, which the students made arrangements for their families to take home, using skills and techniques taught in class. Extra bouquets and arrangements were made that Friday and delivered around town by students. The local businesses that the FFA chapter delivered to includes; Creature Comforts Veterinary, Jell’s Sports Grill, Taffy’s, Sarah’s Pizza, Just Teasin’, Alley cat Tattoo, Hometown Furniture, U.S. Bank, China Wok, Wings Etc., Eaton Police and Fire Departments, Vancrest Health Care Center, Greenbrier Nursing Center, Preble County Medical Center, and the Preble County YMCA.The students also caroled Christmas songs at Vancrest Health Care Center in the assisted living lobby. It was a memorable night for both the students and residents as the FFA chapter sang traditional Christmas songs and handed out flowers. The residents invited the chapter to come back each year and start a new tradition for the Eaton FFA Chapter.
Construction detailsHere are the details as provided by Cascade Built:Exterior walls: Wood-framed 2×6 walls are sheathed with OSB and insulated with blown-in fiberglass in the cavities plus 4 inches of Roxul mineral wool on the exterior (for a total of R-39).Roof: Framed with 11 7/8-inch I-joists and insulated with blown-in fiberglass plus an additional R-15 of polyisocyanurate insulation (for a total of R-63).Foundation: Stem walls for the concrete foundation and crawl space are insulated to R-20, and the floors are insulated to R-38.Windows: Three of the townhouses have double-pane Zola windows; the solar heat gain coefficient (glazing only) of these windows is 0.62, and the whole-window U-factor is 0.21. The other two townhouses have triple-glazed Zola windows with a glazing-only SHGC of 0.5 and a whole-window U-factor of 0.14.Mechanicals: Heating and cooling is provided by ductless minisplit air-source heat pumps. All units have Zehnder Model CA 350 heat-recovery ventilators for whole-house ventilation.Airtighness: The Passivhaus-certified unit had a blower-door test at 0.5 air changes per hour at a pressure difference of 50 pascals (ach50). The other four units tested at approximately 1 ach50.Domestic hot water: On-demand gas-fired water heaters.Renewable energy systems: Units are pre-wired for photovoltaic arrays and electric car charging. The Seattle developer who built the city’s first single-family Passivhaus has completed construction of “View Haus 5,” a five-unit townhouse project that includes one unit built to the Passivhaus standard.It would be the first townhouse in the city to earn Passivhaus certification. The builder is Cascade Built, whose owner, Sloan Ritchie, built “Park Passive,” a three-story home that was completed in 2013.The townhouses were designed by b9 architects. Among the Passivhaus consultants who worked on the project were Mike Eliason of Brute Force Collaborative and Joe Giampietro of NK Architects (the company which designed the Park Passive project). The units range in size from 1,100 to 1,700 square feet and have either two or three bedrooms. Each townhouse is three stories and has two bathrooms.Each of the units has a different look, but only one of them will be submitted for certification by the Passive House Institute U.S.“All units were built using Passive House techniques to achieve a significant reduction in energy use to heat and cool the house,” developers explained in an e-mail. “Passive House is an unknown for many buyers and as a result it’s difficult to secure the needed ROI to make a project like this financially feasible. This project is located on an urban lot in a dense city neighborhood and would have required each unit to be modeled separately, resulting in additional and prohibitive cost increases, so we modeled one unit to Passive House levels and used that same wall assembly for every unit.”One of the two-bedroom units is listed for sale at $690,000 ($403 per square foot), similar in price to a slightly smaller non-Passivhaus two-bedroom nearby, which is on the market for $650,000.
Liverpool loanee Kane signs new extensionby Freddie Taylor10 months agoSend to a friendShare the loveLiverpool have penned Herbie Kane to a new contract and extended his loan spell with Doncaster Rovers.The 20-year-old midfielder has starred for League One side Rovers this season, scoring six goals from 26 appearances.”It is massive, coming from a massive club like Liverpool, so I’m happy,” Kane said after signing the new deal.”I was excited to get it done. It took a lot of hard work to get this, but thankfully it is done. Hopefully I can carry on working hard and get to where I want to be.”On his spell with Donny, he added: “I’ve enjoyed every minute of it, to be honest, I’m just trying to do as well as I can for myself and help the team, but also trying to improve.”Hopefully people at Liverpool notice that I’m doing well, and hopefully when I come back to Liverpool it will impact it.”My aim is to come back in the summer and try to make a footprint. I’m hoping I come back in the summer and impress the manager in pre-season.” TagsTransfersAbout the authorFreddie TaylorShare the loveHave your say
Ohio State 11-18230%22% ▲ 216% Florida State 10-2138100%<1% ▲ 21<1% TeamCFPEloFPIConf. TitlePlayoffNat. Title Washington St. 8-42044530%<1% ▲ 21<1% Oklahoma 11-1331100%99% ▲ 3541% Notre Dame 10-26139—a<1% ▼ 21<1% We can think of the four playoff positions as belonging to the following teams: UCLA 8-42235210%<1% ▲ 21<1% Michigan St. 11-1541462%60% ▲ 138% Mississippi St. 8-42125220%<1% ▲ 21<1% Oklahoma looked impressive. Clemson and Alabama held their ground at the top. Iowa and Michigan State are now on a collision course. Stanford and North Carolina remain in the hunt, but don’t control their own fate. Ohio State lurks in the background.So ends the final weekend of regular-season college football. Now the conference championships will decide which four teams make the playoff. There were 13 teams in contention for a playoff spot going into this past weekend; coming out, only eight of them realistically have a shot now.Here are our updated projections following the Thanksgiving weekend games. (These numbers will change again on Tuesday night after the new committee rankings are released.) Utah 9-32337280%<1% ▲ 21<1% TCU 10-2191060%<1% ▲ 21<1% Alabama 11-121274%79% ▲ 1525% Toledo 9-22432480%<1% ▲ 21<1% Stanford 10-2961148%10% ▼ 6a2% Michigan 9-31021190%<1% ▼ 7a<1% Northwestern 10-21618560%<1% ▲ 21<1% Navy 9-21530440%<1% ▲ 21<1% RankingProbability of … Oklahoma St. 10-21119170%<1% ▼ 10<1% North Carolina 11-11491544%16% ▲ 6a2% Clemson 12-015756%74% ▲ 2113% Mississippi 9-3181150%<1% ▲ 21<1% Florida 10-212222326%<1% ▼ 12<1% Temple 10-225274947%<1% ▲ 21<1% Iowa 12-04122638%39% ▲ 8a3% Baylor 9-271740%<1% ▼ 21<1% College Football Playoff (CFP) rankings as of Nov. 24. Playoff probability changes are since Nov. 25; only changes greater than 5 percentage points are shown. Oregon 9-3177250%<1% ▲ 21<1% Oklahoma. Oklahoma wrapped up its regular season by winning the Big 12 championship on Saturday night, after an 58-23 domination of Oklahoma State. The Sooners now must wait for the final committee rankings to be released on Dec. 6, but by our model’s estimation they are shoo-ins to make the playoff (99 percent).Iowa or Michigan State. The Big Ten title match between Iowa and Michigan State is a de facto play-in game: the winner is almost certainly getting in the playoff. Michigan State is a 64 percent favorite according to the Football Power Index (FPI), and if the one-loss Spartans do prevail, our model gives them a 96 percent shot at making the playoff. If instead the undefeated Hawkeyes win, they’re in the playoff in 98 percent of our simulations.Alabama or an open slot. Alabama won on Saturday and will face Florida for the SEC championship. The Tide’s playoff odds rose to 79 percent, while Florida’s fell to below 1 percent following an ugly loss to Florida State. That means even an upset of Alabama probably wouldn’t be enough to get the Gators in. Instead, a Florida win could open the door for Ohio State or Stanford (if Stanford wins the Pac-12 title game — only about a 50/50 proposition, according to FPI). Our model even thinks there’s an outside shot Alabama could get in despite a loss next weekend, although we doubt the committee will agree.Clemson, UNC or an open slot. Clemson’s an absolute lock if it beats UNC in the ACC championship. If it loses — and the matchup is competitive, according to FPI — what happens next is anyone’s guess. Should UNC beat the Tigers, those odds only rise to 37 percent, meaning there’s a chance the committee could opt for Ohio State or Stanford instead. It’s also theoretically possible the committee could choose Clemson ahead of UNC even if Clemson loses, deciding Clemson’s superior schedule outweighed its head-to-head loss.
The Delta Routine has graced several stages with its rock ‘n’ roll, but the band isn’t so familiar with Columbus – and its about to change that this weekend. The Milwaukee-based group is scheduled to perform in Columbus 7 p.m. Sunday at Scarlet & Grey CafÃ©. Lead vocalist and guitarist Nick Amadeus said the band is looking forward to the Columbus tour stop and the fresh audience to come with it. He added the band has toured through parts of Ohio before but is excited to tour elsewhere in the state. “Cleveland was a little bit weird,” Amadeus said, laughing. “We wanted a change-up.” Amadeus also said The Delta Routine has drawn some of its influences from rock band Hero Jr., an Indianapolis-based band that is touring with The Delta Routine. Columbus-based band Up All Nights is also scheduled to perform with the groups at Scarlet & Grey Sunday. Comprised of Amadeus, keyboardist and vocalist Al Kraemer, guitarist and vocalist Victor Buell IV, bassist and vocalist Evan Paydon and drummer Kyle Ciske, The Delta Routine has had numerous lineup changes in members and instruments since its formation seven years ago. Amadeus said the band found some of its current members by chance at a fashion show. Another important part of the group though is its producer Mike Hoffman, who came across the band due to being a family friend of Amadeus. He’s been with the band from the group’s release of its self-titled debut album in 2007 up to its fourth and most recent release “Cigarettes and Caffeine Nightmares” Oct. 9. “Nick and the guys are very driven, inspired chaps. You know, the only kind I’ll work with,” Hoffman said in an email. “You gotta have rocket fuel in your veins if you’re gonna go anywhere. These guys are tanked up and ready to launch, always.” Referring to The Delta Routine’s music as rock ‘n’ roll with a bit of a pop element, Amadeus said he normally tries to take the lead on the songwriting aspect of albums by laying down some lyrics, then getting the main beat. He said, however, the band’s last album was a collaborative effort from the group. Brett Ruland, owner of Spoonful Records located at 116 E. Long St., said the rock scene is still very popular in Columbus and the turnout at The Delta Routine’s show should be pretty large. “That genre always sells well,” Ruland said. “Indie and rock are the bestsellers here.” Although Ruland said he has never heard of The Delta Routine, he said he’s open to listening to its music and getting himself and others in the rock ‘n’ roll scene familiar with it. Scarlet and Grey is located at 2203 N. High St. and will charge a $5 to $10 cover charge at the door for Sunday’s show.